 
Article Date: 06 Oct 2010 – 2:00 PDT
An impressive body of knowledge has linked stress to illness vulnerability. Yet stress is inextricably linked to everyday life. So when does it hurt?
Allostatic load reflects the cumulative effects of stressful experiences in daily life. When the cost of chronic exposure to fluctuating or heightened neural or neuroendocrine responses exceeds the coping resources of an individual, allostatic overload ensues. In this paper, clinimetric criteria for the determination of allostatic overload are suggested. They are based on: (a) the presence of a stressor exceeding individual coping skills, and (b) clinical manifestations of distress.
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