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January 2011



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Rachel Feldman – University of Haifa

Use of cannabinoids, the active chemicals in cannabis (marijuana), could assist in the treatment of post-traumatic stress disorder patients according to a recent study published in the Journal of Neuroscience.

In most cases, the result of experiencing a traumatic event – a car accident or terror attack – is the appearance of medical and psychological symptoms that affect various functions, but which pass. However, some 10%-30% of people who experience a traumatic event develop post-traumatic stress disorder, a condition in which the patient continues to suffer stress symptoms for months and even years after the traumatic event. Symptoms include reawakened trauma, avoidance of anything that could recall the trauma, and psychological and physiological disturbances. One of the problems in the course of treating trauma patients is that a person is frequently exposed to additional stress, which hinders the patient in overcoming the trauma.

The present study, conducted by Dr Akirav and research student Eti Ganon-Elazar of the Learning and Memory Lab at the University of Haifa’s Department of Psychology, aimed to examine the efficiency of cannabinoids as a medical treatment for coping with post-traumatic stress. The researchers used a synthetic form of marijuana, which has similar properties to the natural plant, and they chose to use a rat model, which presents similar physiological responses to stress to that of humans.

The first stage of the research examined how long it took for the rats to overcome a traumatic experience, without any intervention. A cell colored white on one side and black on the other was prepared. The rats were placed in the white area, and as soon as they moved over to the black area, which they prefer, they received a light electric shock. Each day they were brought to the cell and placed back in the white area. Immediately following exposure to the traumatic experience, the rats would not move to the black area voluntarily, but a few days later after not receiving further electric shocks in the black area, they learned that it is safe again and moved there without hesitation.

Next, the researchers introduced an element of stress. A second group of rats were placed on a small, elevated platform after receiving the electric shock, which added stress to the traumatic experience. These rats abstained from returning to the black area in the cell for much longer, which shows that the exposure to additional stress does indeed hinder the process of overcoming trauma.

The third stage of the research examined yet another group of rats. These were exposed to the traumatic and additional stress events, but just before being elevated on the platform received an injection of synthetic cannabinoids in the amygdala area of the brain – a specific area known to be connected to emotive memory. These rats agreed to enter the black area after the same amount of time as the first group – showing that the cannabinoids cancelled out the symptoms of stress. Refining the results of this study, the researchers then administered synthetic cannabinoids injections at different points in time to additional groups of rats, and found that regardless of when exactly the injection was administered, it prevented the surfacing of stress symptoms.

Dr Akirav and Ganon-Elazar also examined hormonal changes in the course of the experiment and found that the synthetic cannabinoids prevent increased release of the stress hormone that the body produces in response to stress.

According to Dr Akirav, the results of this study show that cannabinoids can play an important role in stress-related disorders. “The results of our research should encourage psychiatric investigation into the use of cannabinoids in post-traumatic stress patients,” she concludes.

Ganon-Elazar E, Akirav I. Cannabinoid receptor activation in the basolateral amygdala blocks the effects of stress on the conditioning and extinction of inhibitory avoidance. J Neurosci. 2009 Sep 9;29(36):11078-88   [Abstract]


There is a great deal of difference between medical grade synthetic cannabinoids and street grade marijuana. Not only is it free of naturally occurring but potentially harmful substances found in the cannabis plant, there is also no risk of it being laced with other drugs sometimes added to provide additional ‘kick’ such as phencyclidine (Angel Dust), or adulterated with glass beads, lead, even embalming fluid to add weight.

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