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Published: September 23, 2009

Dr. Leon Eisenberg, who conducted some of the first rigorous studies of autism, attention deficit disorder and learning delays and became a prominent advocate for children struggling with disabilities, died on Sept. 15 at his home in Cambridge, Mass. He was 87.

The cause was prostate cancer, said his wife, Dr. Carola Eisenberg.

The field of child psychiatry was dominated by Freudian psychoanalysis when, in the late 1950s and 1960s, Dr. Eisenberg began conducting medical studies of children with developmental problems. Working at Johns Hopkins University with Dr. Leo Kanner, who first described autistic behavior, Dr. Eisenberg completed the first detailed, long-term study of children with autism, demonstrating among other things that language problems predicted its severity.

In a similar study among children who were developing normally, Dr. Eisenberg showed that reading difficulties early in school predicted behavior problems later on.

In the 1960s, he performed the first scientific drug trials in child psychiatry, testing stimulants like Dexedrine and Ritalin to soothe the behavior of children identified as “delinquent” or “hyperkinetic.” These studies, which became the basis for drug treatment of what is now called attention deficit disorder, ran counter to psychoanalytic theories on the most effective treatments.

“Leon took a very courageous stand and denounced the way psychiatry treated children, this whole system in which we had a few rich kids and their parents getting psychoanalysis five days a week and still not being cured,” said C. Keith Conners, a professor emeritus in the department of psychiatry and behavioral sciences at Duke University. “No one even knew what a cure looked like. He had this conviction that nothing was being done for the bulk of children who needed help, and that we had very little scientific data to guide us.”

Dr. James Harris, a professor of psychiatry and behavioral science at Johns Hopkins University, said that Dr. Eisenberg was “the pivotal person in 20th-century child psychiatry who moved the field from simple descriptions of childhood disorders to actually looking at the science behind both the diagnosis and treatment.”

Read in Full:  http://www.nytimes.com/2009/09/24/health/research/24eisenberg.html?_r=2&ref=health

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