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January 2011



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Behavioral Problems in Childhood Doubles the Risk of Chronic Widespread Pain in Adult Life

ScienceDaily (Mar. 9, 2010) — Bad behaviour in childhood is associated with long-term, chronic widespread pain in adult life, according to the findings of a study following nearly 20,000 people from birth in 1958 to the present day.

Chronic widespread pain is a common complaint that can have a major adverse effect on quality of life, often requiring referral to a hospital specialist for investigation and treatment. The research, published online in the journal Rheumatology on March 10, found that children with severe behaviour disturbances had approximately double the risk of chronic widespread pain by the time they reached the age of 45 than children who did not have behaviour problems.

The researchers found that this association was not explained by social class, early reporting of symptoms or an already-known link between adult psychological distress and chronic widespread pain (CWP). Instead, they believe that a dysfunction in the interaction between the nervous system and hormones, occurring in early life, may have long-term consequences for adult health.

The lead author of the study, Dr Dong Pang, an epidemiologist at the University of Aberdeen (UK), said: “We know already that severe adverse events in childhood such as hospitalisation after a road traffic accident and separation from mothers are linked to CWP in adulthood. In addition, aspects of childhood behaviour are strongly related to children reporting CWP. However, until now, it was unknown whether maladjusted behaviour in children was a long-term marker for CWP in adulthood. Our study shows that it is.

“We are not sure what underlying biological mechanism underpins this relationship, but one possible explanation might be that both the childhood behaviour and the adult CWP are due to a long-term neuroendocrine dysfunction beginning in early life. The hypothalamic-pituitary-adrenal (HPA) axis, the primary neuroendocrine stress response system, has been shown to be associated with childhood behaviour. Similarly, altered HPA axis function has been reported to be associated with CWP. Early life experience, such as emotional stress due to past trauma, may have a lifelong impact on the neuroendocrine system (HPA axis), which in turn leads to behavioural problems in childhood and CWP in adulthood as well as other mental problems. Further research at molecular and genetic level are needed to clarify this.”

The researchers followed a group of 18,558 children who were born in one week in 1958 in England, Scotland and Wales, and an additional 920 children who were born in the same week overseas and who came to the UK before the age of 16. Information was collected at regular intervals, including at the ages of 7, 11 and 16, and at 42 and 45 in adulthood. Parents and teachers independently assessed the children’s behaviour on aspects such as restlessness, worrying, solitariness, ability to make friends, obedience, stealing, sucking thumbs and biting nails, lying, bullying, truanting etc. At the age of 42 the participants completed a questionnaire asking about psychological distress in adult life, and at the age 45 they completed another one about pain.

The study found that CWP was slightly more common in women than in men (12.9% versus 11.7%). Children whose teachers had reported severe persistent behaviour problems at all ages (7, 11 and 16) had more than double the risk of CWP in adulthood compared with children without behaviour problems at all ages. If the children had severe behaviour problems at 11 and 16, then they had nearly double the risk of CWP in later life. Similar, but weaker associations were shown for parent-reported behaviour, which the researchers believe is because teachers tend to be better at providing objective assessments of behaviour as they have more children to compare.

The researchers say that it is not just CWP that is associated with bad behaviour in childhood. Other adult problems that are associated with childhood behavioural problems include long-term psychiatric problems such as depression and anxiety, suicidal behaviour, substance abuse and treatment for psychiatric illness. They suggest that all these problems may be outcomes of the chain of events set in motion by the dysfunctioning neuroendocrine system. If further research proves this to be the case, then it might be possible to intervene in early life to prevent these problems occurring later.

Professor Gary Macfarlane, the leader of the research group, said: “This study helps us to understand the factors in childhood that can lead someone to get on a trajectory of ill-health, including chronic pain. The disruption to the hypothalamic-pituitary-adrenal (stress-response) axis is one biological marker of the effect of such experiences and this could help to identify persons at higher risk of chronic pain. Interventions would be lifestyle focussed and would include identification and treatment of behavioural and emotional factors, but would also address lifestyle factors such as increased physical activity.

“We plan to undertake some studies in children to understand what range of factors cause a disturbance to the stress-response axis; such work can then inform what intervention studies may be appropriate.”

Journal Reference:

  1. Dong Pang, Gareth T. Jones, Chris Power and Gary J. Macfarlane. Influence of childhood behaviour on the reporting of chronic widespread pain in adulthood: results from the 1958 British Birth Cohort Study. Rheumatology, (in press) DOI: 10.1093/rheumatology/keq052



Childhood Stress Can Result in Brain Changes

By Rick Nauert PhD Senior News Editor
Reviewed by John M. Grohol, Psy.D. on March 1, 2010

Researchers report that magnetic resonance imaging (MRI) can detect structural changes in the brain among abused or emotionally neglected children.

The alterations appear to occur when children with a particular genetic makeup are abused predisposing the child to depression.

The study was led by scientists at Trinity College Dublin and is published in the international scientific journal, Neuropsychopharmacology.

Commenting on the significance of the findings, Trinity’s Professor Thomas Frodl at the School of Medicine and Trinity Institute for Neuroscience said:

“This improved neurobiological understanding shows how stress and genetic variants interact and affect brain structure and function. In turn it demonstrates how it could affect a person’s propensity for depression. These structural alterations of the brain are associated with a higher vulnerability to depression and a more chronic course of the depression might be associated with further structural changes”.

“Therefore, early intervention in the case of major depression is necessary to increase the chance of a good disease outcome. Fortunately, depression can be treated very well by psychotherapy and antidepressant medication. Moreover, prevention strategies for childhood neglect and misuse are highly important to increase public health and to avoid in later life for these individuals, the burden of major depression.”

The world health organization (WHO) found that major depression is one of the most important human diseases with a prevalence of about 10% worldwide. Approximately 500,000 people in Ireland have or will develop major depression in their life. The WHO has forecast that major depression will be the second most common cause of disability by 2020. Advances in this area will have a high impact on overall disease costs.

The study was conducted on a total of 24 patients (aged 18-65 years) being treated as inpatients for major depression. They were investigated with high-resolution structural MRI and childhood stress assessments. Special analysis programs were used to measure brain regions. These patients were compared with 27 healthy control subjects from the local community who were matched for age and gender.

Further research is needed in a larger number of patients and controls to identify the underlying causes of depression and stress-gene interaction on brains structure as well as function.

Source: Trinity College Dublin

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