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Maletic V, Raison CL, Jain R, Draud JW.

As we begin this brief review of the neurobiology of major depressive disorder (MDD), we face these fundamental questions:

• Will the provided information be clinically relevant?
• Can current scientific research provide us with a coherent, comprehensive, and relatively accurate description of the underlying neurobiology of MDD?

Major depression, bipolar disorder (BD), and generalized anxiety disorder (GAD) are all characterized by a significant genetic contribution to their etiopathogenesis.