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W.B. Groen1,2,3, C. Tesink2,3, K.M. Petersson3,4, J. van Berkum4, R.J. van der Gaag1,2, P. Hagoort3,4 and J.K. Buitelaar1,2 

1 Karakter, Child and Adolescent Psychiatry University Center, Karakter, 6525 GC Nijmegen, the Netherlands, 2 Department of Psychiatry, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, the Netherlands, 3 Donders Institute for Brain, Cognition and Behavior, Center for Cognitive Neuroimaging, Radboud University Nijmegen, Donders, 6500 HB Nijmegen, the Netherlands, 4 Max Planck Institute for Psycholinguistics, Max, 6525 XD Nijmegen, the Netherlands

 

Address corresponding to Wouter Bastiaan Groen, MD, P.O. Box 9101, 6500 HB Nijmegen, the Netherlands. Email: w.groen@psy.umcn.nl.

Language in high-functioning autism is characterized by pragmaticand semantic deficits, and people with autism have a reducedtendency to integrate information. Because the left and rightinferior frontal (LIF and RIF) regions are implicated with integrationof speaker information, world knowledge, and semantic knowledge,we hypothesized that abnormal functioning of the LIF and RIFregions might contribute to pragmatic and semantic languagedeficits in autism.

Read in Full:  http://cercor.oxfordjournals.org/cgi/content/short/20/8/1937?rss=1



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