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 Seizure Meds May Up Risk Of Mental Disorders

By Rick Nauert PhD Senior News Editor
Reviewed by John M. Grohol, Psy.D. on October 23, 2009

Professionals acknowledge that a history of seizures during infancy increases the risk for development of schizophrenia later in life.

A new study among animal models reveals antiepilectic drug treatments (AED) administered when the brain is developing triggers schizophrenia-like behavior in animals.

The finding brings to question if the seizures, their treatment or perhaps both, increase the risk for schizophrenia in humans.

In research presented at the 39th annual meeting of the Society for Neuroscience, Georgetown University Medical Center researchers show that exposure to AEDs during critical periods of brain development in animal models increases schizophrenia-like behaviors.

“We know that early-life exposure to AEDs such as phenobarbital triggers cell death in many brain regions associated with the onset of schizophrenia,” explains Guillermo Palchik, a doctoral student in the department of pediatrics at GUMC.

“This study not only suggests a relationship between the drugs and schizophrenia, but it raises important questions regarding the side effects of a widely-used class of drugs.

Read in Full:  http://psychcentral.com/news/2009/10/23/seizure-meds-may-up-risk-of-mental-disorders/9123.html

 Mental Disorders Associated With Urinary Tract Disorders

By Rick Nauert PhD Senior News Editor
Reviewed by John M. Grohol, Psy.D. on October 22, 2009

A new study finds an association between depression, anxiety disorders, sexual trauma and lower urinary tract symptoms.

The medical disorders include incontinence and overactive bladder although the exact nature of the correlations is unknown.

In a study published online in The Journal of Urology, researchers from the Division of Urology, Virginia Commonwealth University School of Medicine and the Hunter Holmes McGuire Veterans Affairs Hospital, Richmond, Virginia, explored the possible association of LUTS with those factors.

Two questionnaires, the Urogenital Distress Inventory-6 and Incontinence Impact Questionnaire-7, were administered to 121 women referred to a specialized urology clinic for evaluation of lower urinary tract symptoms.

These data were then analyzed according to psychiatric comorbidities, history of sexual trauma, age, race and obstetric history. Baseline incidence of psychiatric comorbidity and sexual trauma was also compared to a control population of 1,298 women from the Veterans Affairs primary care clinic.

Women referred for evaluation of lower urinary tract symptoms had higher rates of psychiatric comorbidities (64.5 percent vs. 25.9 percent) and sexual trauma (49.6 percent vs. 20.1 percent) compared to those in the primary care clinic.

Read in Full:  http://psychcentral.com/news/2009/10/22/mental-disorders-associated-with-urinary-tract-disorders/9110.html



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